Antinuclear Antibodies (ANA) Comprehensive Profile

CPT Test code: 86225;86235

Test Includes:	Anticentromere B antibodies; anti-dsDNA; antichromatin antibodies; anti-Jo-1; RNP antibodies; antiscleroderma 70 antibodies; Smith antibodies; Sjögren anti-SS-A; Sjögren anti-SS-B
Specimen:	Serum
Volume:	1 mL
Minimum Volume:	0.5 mL (Note: This volume does not allow for repeat testing.)
Container:	Red-top tube or gel-barrier tube
Special Instructions:	Test is intended to be used as a follow-up to Antinuclear Antibodies (ANA) Direct [164855].
Storage Instructions:	Maintain specimen at room temperature.
Causes for Rejection:	Hemolysis; lipemia; gross bacterial contamination; icterus
Use:	Detect antibodies associated with SLE and mixed connective tissue disease. Anti-Sm is highly specific for SLE. Anti-RNP is found with a variety of rheumatoid diseases. RNP, Sm, SS-A, SS-B, Scl-70, and Jo-1 are extractable nucleoprotein complexes found in the nucleus and/or cytoplasm of substrate cells.
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