Detection of IgG antibodies to either HSV-1 and/or HSV-2
Specimen:
Serum
Volume:
1 mL
Minimum Volume:
0.5 mL
Container:
Red-top tube or gel-barrier tube
Storage Instructions:
Refrigerate.
Causes for Rejection:
Excessive hemolysis; lipemia; gross contamination
Reference Interval:
Negative: <0.9 index
Use:
Detect IgG antibodies to either HSV-1 and/or HSV-2
Additional Information:
Conventional HSV-1 and HSV-2 assays cannot differentiate HSV type 1 from HSV type 2 infection due to the extensive homology of viral antigens. Antibodies formed against either virus are highly cross reactive. An HSV-2 type-specific IgG assay based on glycoprotein G-2 is available for differentiating HSV-1 from HSV-2 infections.
References:
Ashley R, Cent A, Maggs V, Nahmias A, Corey L. Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types I and II. Ann Intern Med. 1991 Oct 1; 115(7):520-526. PubMed 1652909
Corey L. The current trend in genital herpes. Progress in prevention. Sex Transm Dis. 1994 Mar-Apr; 21(2 Suppl):S38-544. PubMed 8042114
Whitley RJ. Herpes simplex virus infections of women and their offspring: Implications for a developed society. Proc Natl Acad Sci USA. 1994 Mar 29; 91(7):2441-2447 (review).PubMed 8146137
